Also pitch shifting after the preamp can be problematic. The tubes makes some lovely harmonics that pitch shifters can struggle to track, the IPS33 has a distortion send return loop so it gets the direct sound from the guitar which it uses to track the signal and then applies the harmonies to the distorted tube signal. So for a while I plugged the guitar into the IPS33 input, took the dist loop output into the MP1, then MP1 returns into 2 desk channels, then FX send 3 (of both channels) to the IPS33 dist loop return. Worked fine but the IPS33's input is on the back (a hassle) so eventually I stopped bothering and just ran FX send 3 to its input, I didn't notice a marked difference so went with that. But as Soloist said, an intelligent pitch shift helps (the IPS33 was one of the first, you can tell it what key your in and it adjusts accordingly). Panning can also move the harmonies in you stereo mix (sound stage) to get more definition, while I used hard panning, with the small desk I use, I can do that also (but haven't needed to).