Had a listen, the Marshall sound is alive and full of energy (as you say 50 w compared to 5 w).
In this it's so hard to compare apples with apples, in the end, it's just "does it sound good/what do I want". There are a bunch of variables, amp, tube, guit, player the list goes on as they all make part of the sound. I agree, the KT66 in the pico are probably the go, each sound had it's merits but all round I'd also pick that combination. But you can't really compare that with the first Marshall (easily) as it was by far the best in many ways but the most "ragged"
and a large part of that was probably 50w cranked (well you probably weren't doing the full 50 ?).
With MP1/2 I go for clean transparent power amp. I used a B200s for years and loved it (it just wasn't there, except I had lots of grunt). I currently use a Carvin TS100 all tube amp. it claims to be a good amp for studio monitors (very clean/transparent), anyway works a treat, love it, a bit heavy though (as are all tube amps), my version is running the 6L6s' (I may try some 6CA7/EL34s in it next tube change (it takes both, switchable), as you say tubes here will make a subtle difference, and compare apples with apples). I don't expect a huge difference though as all my tones are coming from my fingers/guit/MP2. It's a little more finicky with the MP1/2 input tubes, there seems to be more variations at this point of the circuit (but again, if you've selected decent tubes, the differences are (mostly) subtle). And I should add subjective.
Cheers R