I did a little of it, but it turned out to be kind of annoying. It would be a lot easier/better if I had an amp switcher, but that is not something I am going to put money in to at this time.
Basically, by the time I get it switched, I've lost what the other was like exactly. What I can do though, is go back and re-do some of the recordings I did with the Syn-30 and compare them that way. I have notes on what my settings were, even though it's not necessarily an exact translation on settings.
What I can say so far is this: The Syn-30 + SLO module *really* captures the vibe, and better so than any modelers I have used (Pod XT, Pod HD, Helix, and Axe FX III).
The SLO does have something going on that I don't know how to describe, but it is definitely different. Some have described it as '3d' and I have no idea what that means. But there is a presence and clarity that the Synergy doesn't quite have. It's not like having a blanket over the amp compared to the SLO, but maybe a sheet?
It also seems to stand out/sit in a mix a bit better too. I get what Mike Nielson meant when he said the Soldano has a "Hey, look at me!" tone. The Synergy has the SLO tone, but it's missing that factor, whatever is giving it to the SLO.
I did do a little clip with much higher gain than I would normally ever use, and the SLO still manages to retain some clarity and definition.