Metal Zone!!!! All the gain!!! Scoop the mids!!!! (Sorry, couldn't resist).
A lot of things in the chain can be thought of as EQ. Pickups, Amp, Speakers, Mic, pedals (Thinking of things like using a tube screamer for a clean boost - it's still applying EQ to the signal). Now that I'm back to head and cab (and a rack unit, but I'm using the rack unit like a pedalboard) I'm not using any extra EQ from that. But, then I didn't back when I used a full rack unit (Only used EQ in the MP1) and I didn't use extra EQ stages when I was using the Line 6 stuff either.
About the only one I will use is occasionally an overdrive/boost sometimes to shape the gain, but even then, I prefer to be able to get the sound I'm looking for just from guitar, amp and speakers. If I'm not getting it, I'm much more likely to swap something out in that area.